Kirk P. Manfredi
Department of Chemistry
University of Northern Iowa
Phone: 319-273-2295 (chemistry office 3-2437)
Email: manfredi@uni.edu

I'm in the middle at the RMC all 70's reunion held in October 2007. My former chemistry professor, Ray Graham is on my right and his wife Pat on my left.

Over the past 15 years our research has been in the area of natural products isolation and structure elucidation. Most of our current work has been involved in isolating compounds from native prairie plants. We have had a collaboration with Dr. Kelly Kindscher of the Kansas Biological Survey for the past few years. This collaboration has resulted in the collection and identification of over 50 native plant species that have been shown to have medicinal uses by Native Americans of the Missouri River region. We have collaborations with various labs to bioassay compounds for activity against human tumor cells lines, HIV (NCI) and M. tuberculosis (TAACF). We are currently developing bioassays to investigate the immune enhancement properties of various prairie plant extracts..

Recent Publications

Kindscher, K; Manfredi, K. P.; Britton, M.; Demidova, M. and Hurlburt, B. "Testing Prairie Plants with Ethnobotanical Importance for Anti-Cancer and Anti-AIDS Compounds" J. Ethnobiology 1998 18(2):229-245.

Manfredi, K. P., Valurupalli, V., Demidova, M., Pannell, K.L., Kindscher,K. "Isolation of an anti-HIV diprenylated bibenzyl from Glycyrriza lepidota" Phytochemistry 58, (2001) 153-157.

Curtis C. Barnes, Mary K. Smalley, Kirk P. Manfredi, Kelly Kindscher, Hillary Loring and Douglas M. Sheeley " Characterization of an Anti-tuberculosis Resin Glycoside from the Prairie Medicinal Plant Ipomoea leptophylla" J. Nat. Prod. 2003 (66) 11, 1457-1462.

L.A. Beltz* and K. P. Manfredi “An Update on the Other Telomerase Inhibitors: Non-G-Quadruplex Interactive Agents, Non-Antisense, Non-Reverse transcriptase Telomerase Inhibitors” Medicinal Chemistry Reviews-Online 2005 2(4) 325-343.

OFFICE HOURS Fall 2009: 9:00-11:00 AM MWF
(You may also make an appointment via email or phone call)