Kirk P. Manfredi
Department of Chemistry
University of Northern Iowa
Phone: 319-273-2295 (chemistry office 3-2437)
Email: manfredi@uni.edu
Above is a photograph from August 2017 taken at Fort Detrick, Frederick, MD. The occasion was a retirement party for the lab chief Jim McMahon (far right). The people in the photograph are the Òold timersÓ from the LDDRD lab (now called MTL).I was at the lab from 1989-1991. It was clearly where I learned about natural products research.Kirk Gustafson (far left), Rich Fuller(red hat) and John Cardellina (not pictured)were the first four natural products chemists in the lab.
Over the past 15 years our research has been in the area of natural products isolation and structure elucidation. Most of our current work has been involved in isolating compounds from native prairie plants. We have had a collaboration with Dr. Kelly Kindscher of the Kansas Biological Survey for the past few years. This collaboration has resulted in the collection and identification of over 75 native plant species that have been shown to have medicinal uses by Native Americans of the Missouri River region. We have collaborations with various labs to bioassay compounds for activity against human tumor cells lines and HIV.We are also trying to develop botanicals as use as preservatives in personal care products.In addition to prairie plant research we have recently begun an investigation into antimicrobial compounds produced by fungus. We are growing fungus on various carbon substrates and examine changes in their metabolism.
Recent Publications
Kindscher, K; Manfredi, K. P.; Britton, M.; Demidova, M. and Hurlburt, B.
"Testing Prairie Plants with Ethnobotanical
Importance for Anti-Cancer and Anti-AIDS Compounds" J. Ethnobiology
1998 18(2):229-245.
Manfredi, K. P., Valurupalli, V., Demidova,
M., Pannell, K.L., Kindscher,K.
"Isolation of an anti-HIV diprenylated bibenzyl from Glycyrriza lepidota" Phytochemistry 58,
(2001) 153-157.
Curtis C. Barnes, Mary K. Smalley, Kirk P. Manfredi, Kelly Kindscher,
Hillary Loring and Douglas M. Sheeley
" Characterization of an Anti-tuberculosis Resin Glycoside from the
Prairie Medicinal Plant Ipomoea leptophylla" J. Nat. Prod.
2003 (66) 11, 1457-1462.
L.A. Beltz* and K. P. Manfredi ÒAn Update on the
Other Telomerase Inhibitors: Non-G-Quadruplex
Interactive Agents, Non-Antisense, Non-Reverse transcriptase Telomerase
InhibitorsÓ Medicinal
Chemistry Reviews-Online 2005 2(4) 325-343.
Miesner, S.; Frosch, H.; Kindscher, K.; Tichy, S. and Manfredi, K. Benzyl Benzoate Glycosides from Oligonurion rigidum J.Nat. Prod. 2012, 75, 1903-1908.
Jordan A. Hein; Mark E. Sherrard, Mark E.; Manfredi ,Kirk P. and Abebe, Tilahun ÒThe Fifth Leaf and Spike Organs of Barley Display Different Physiological and Metabolic Responses to Drought StressÓ BMC Plant Biology 2016, 16:248
Office hours Fall
2017 MWF 9:00-10:00; TTh 1:00-2:00
Class notes and handouts can be
obtained on e-Learning for: ORGANIC 2 CHEM 2220 CHEM 2230 Organic Lab CHEM 4610 Advanced Synthesis Lab Last updated 8-18-17
(You may also make an appointment via email or phone call)